Further experiments with obese non-diabetic or diabetic non-obese mice will help to characterize the separate effects of these risk factors.
The diabetic mice, he said, had had extremely high blood sugar levels for weeks and would die without insulin.
The researchers then injected some of these artificially made islets into diabetic mice.
The gene for human insulin has been transplanted successfully into diabetic mice.
Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.
Finally, work in Oxford on a strain of diabetic mouse is beginning to reveal the genes that govern susceptibility to the disease.
Since these abnormal data were found in diabetic mice, the study concluded that low aconitase activity is likely correlated with genetic and alloxan diabetes.
The study involved non-obese diabetic mice, a breed known to develop fatal diabetes in their first half year of life.
These diabetic mice had a dominant Akita mutation in the insulin-2 gene (Ins2).
When injected under the skin of diabetic mice, they induced the body to build a blood supply to them and enabled the mice to live longer.