The PEPI study findings corroborate those of another large study of a different hormone combination, also published today in the journal.

Women who had a uterus could take the hormone combination.

The other part of the study, of women taking the hormone combination, was the part that was halted.

The hormone combination is now approved in the United States only to treat menopausal symptoms and to prevent the bone-thinning disease osteoporosis.

Ms. Kipfer began taking the hormone combination in April 1991, when she was 44.

She began taking the hormone combination when she was 49, to control the symptoms of menopause.

Procedures development and standardized for estrus synchronization and super ovulation different hormone combinations in cattle and buffaloes.

In that case the hormone combination led to more breast cancer and more heart disease.

The findings on the hormone combination will be published in the July 17 issue of The Journal of the American Medical Association.

It is not known, either, whether the results apply to women who take other hormone combinations or estrogen alone.