If your body isn't making enough of the hormone insulin on its own, you'll have to take it in the form of medication.

This is due to a lack of the hormone insulin, normally produced in the pancreas.

The result is an increasing cellular resistance to the effects of the hormone insulin, which enables cells to burn blood sugar for energy.

Typically, the condition results from the body's failure to properly use the hormone insulin, allowing excess sugar to build up in the blood.

Diabetes is a disease in which the body either does not produce or is unable to use the hormone insulin properly.

In a healthy person, the hormone insulin helps glucose enter the cells.

The sugar is then shuttled by the blood to cells with the help of the hormone insulin.

Beginning in 1922 the laboratories began to mass-produce the newly discovered hormone insulin.

The hormone insulin is required to process glucose and maintain blood levels within a normal range.

The investigators found that when the patients took hydrochlorothiazide, their tissues were less responsive to the hormone insulin.