And he has made mental health his signature issue.

But the Republicans' signature issue was the tax cut.

Another of her signature issues were those relating to the health and well being of women.

But her signature issues have been education and health care.

So far, he has barely moved public opinion on this signature issue from where it was a year ago.

The rise of special interests has become the signature issue of Chinese politics in 2010.

All agreed that Gore is doomed if the treaty becomes his signature issue.

Polls show the president is losing ground among Americans on his signature issue of international security.

But they failed on their signature issue, which was a tax cut in a year with what may be a $70 billion surplus.

Another signature issue is protecting Michigan's precious and diverse natural environment.